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ICU nurses with babyPhilippine General Hospital artworkEach year millions of babies die as a result of infections in the first few weeks of life. There are simple, cost-effective practices to prevent these deaths (like hand-washing, breastfeeding and kangaroo mother care). If these practices were routine, rates of neonatal sickness and death would be substantially reduced.


SEA-URCHIN aims to determine if an intervention to implement research about prevention and management of neonatal infection can improve clinical practice and health outcomes for babies.


SEA-URCHIN is based in the neonatal units of eleven hospitals in Indonesia, Malaysia, Thailand and the Philippines. Prior to the intervention, barriers to preventing and managing neonatal infection will be identified and laboratory practices will be determined in each hospital.

Using an interrupted time series study design, health outcome and clinical practice data will be collected for 100 babies per hospital per month for 12 months before and 12 months after the intervention

The intervention will be tailored to address the identified barriers. It will include fellowships in skills-based training using the ‘SCORPIO’ model, knowledge translation tools, audit and feedback, publicity and policy activities.


It is anticipated SEA-URCHIN will increase our understanding of how to translate research into this specific practice area and lead to improved outcomes for newborn babies in South East Asia.


Kiatchoosakun P, Jirapradittha J, Sirikarn P, Laopaiboon M, Pattanittum P, Chandrakachorn W, Srirojana S, Jeffery H, Green S, Lumbiganon P. Early-Onset Neonatal Sepsis and Antibiotic Use in Northeast Thailand. Am J Perinatol 2018. DOI: 10.1055/s-0038-1676829



Participating Centres

South East Asia

Srinagarind (Khon Kaen University) Hospital; Khon Kaen Regional Hospital; Kalasin General Hospital
Country Investigators: Pagakrong Lumbiganon, Malinee Laopaiboon and Pisake Lumbiganon

Philippine General Hospital and Dr Jose Fabella Memorial Hospital, Manila
Country Investigators: Jacinto Blas III Mantaring and Resti Bautista

Penang Hospital; Hospital Universiti Sains Malaysia, Kelantan and Hospital Raja Perempuan Zainab II, Khota Bharu
Country Investigators: Jacqueline Ho, Hans Van Rostenberghe and Hasmawati Hassan

Dr Sardjito Hospital and Sleman District Hospital, Jogjakarta; Cipto Mangunkusumo Hospital, Jakarta
Country Investigators: Setya Wandita, Mohammad Hakimi and Rinawati Rohsiswatmo


Australasian Cochrane Centre, Monash University
Centre Investigators: Sally Green, Steve McDonald and Joanne McKenzie

International Public Health Unit, University of Sydney
Centre Investigator: Heather Jeffery

School of Medical Sciences, University of New South Wales
Centre Investigator: Monica Lahra

Royal Prince Alfred Hospital
Centre Investigator: David Osborn

Australian Research Centre for Health of Women and Babies, University of Adelaide
Centre Investigator: Caroline Crowther

The SEA-URCHIN Study Group

Project Investigators: Pagakrong Lumbiganon, Malinee Laopaiboon and Pisake Lumbiganon (University of Khon Kaen, Thailand); Jacinto Blas III Mantaring and Resti Bautista (University of Philippines Manila); Jacqueline Ho (Penang Medical College, Malaysia); Hans Van Rostenberghe (Universiti Sains Malaysia, Kelantan); Hasmawati Hassan (Hospita Raja Perempuan Zainab II, Malaysia); Setya Wandita and Mohammad Hakimi (Gadjah Mada University, Indonesia); Rinawati Rohsiswatmo (Cipto Mangunkusumo Hospital, Indonesia); Sally Green, Steve McDonald and Joanne McKenzie (Monash University, Australia); Heather Jeffery (University of Sydney, Australia); Monica Lahra (University of New South Wales, Australia); Caroline Crowther (University of Adelaide, Australia); David Osborn (Royal Prince Alfred Hospital, Australia).

Project Coordinators: Violet Marion (Monash University, Australia); Hatairat Junpeng (Khon Kaen University, Thailand).

Project Administrators: Melissa Murano (Monash University, Australia); Rabieb Poombankor (Khon Kaen University, Thailand).

Statisticians: Malinee Laopaiboon and Porjai Pattanitum (Khon Kaen University, Thailand); Joanne McKenzie (Monash University, Australia).

Senior Research Fellows: Tari Turner and Gabriella Tikellis (Monash University, Australia).

Senior Research Officer: Emily Bek (University of Sydney, Australia).


SEA-URCHIN is funded by a Project Grant from the National Health and Medical Research Council of Australia (No. 1004005)